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REVIEW OF PEDIATRIC RENAL NEOPLASMS
John Hicks
Texas Children's Hospital, Houston, TX

NEPHROBLASTOMA (WILMS TUMOR)

INDEX

 

Nephroblastoma:
Components and Patterns
Three Primary Elements  
  Blastema  
    - diffuse pattern 
    - organoid pattern 
        serpentine 
        nodular 
        basaloid 
  Epithelial-Lined Tubules 
   - tubular pattern 
   - glomeruloid pattern 
   - papillary pattern 
   - pelvicalyceal pattern 
   - cysts/glands 
   - heterologous patterns 
        mucinous 
        squamous 
        neural 
        neuroendocrine 
  Primitive Stroma Cell Types  
   - undifferentiated 
   - myxoid 
   - fiboblastic 
   - smooth muscle 
   - skeletal muscle  
   - cartilage  
   - osteoid/bone  
   - adipose tissue  
   - neural  

 

 

Nephroblastoma: Light microscopy and Ultrastructure
Wilms tumor -lm Wilms tumor - em
Figure 1A: Epithelial area with tubule formation (light microscopy) Figure 1B: Epithelial area with elongated cell attachment (electron microscopy)

 
 

Nephroblastoma: Staging
Stage I:   Tumor confined to kidney and completely resected 
Stage II:  Microscopic residual tumor 
              Tumor penetration through renal capsule 
Stage III: Gross residual disease confined to abdomen 
              Lymph node involvement 
              Diffuse peritoneal contamination (tumor rupture) 
Stage IV: Hematogenous Metastases: lung, noncontiguous liver,  
               bone, and brain 
Stage V:  Bilateral renal involvement at diagnosis

 


INDEX
Congenital Mesoblastic Nephroma
Clear Cell Sarcoma
Malignant Rhabdoid Tumor
Renal Cell Carcinoma
Angiomyolipoma
Ossifying Tumor of Infantile Kidney

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