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1998 Pathologist-In-Training Award |
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| C. Antonescu, P. Argani, RA
Erlandson, M. Laganyi, AG Huvos Skeletal and Extraskeletal Myxoid Chondrosarcoma; A Clinicopathologic, Ultrastructural and Molecular Comparative Study. Memorial Sloan-Kettering Cancer Center, N.Y. Mod Pathol 11: 7A; 1998. |
Do differences exist between extraskeletal myxoid chondrosarcoma and skeletal myxoid chondrosarcoma? Dr. C. Antonescu's answer to this question made her poster, the winning poster for the 1998 Pathologist-In-Training Award.Dr Antonescu and her colleagues examined the biologic behavior, light microscopic features and immunohistochemical profiles of twenty cases of extraskeletal myxoid chondrosarcoma (EMC) and twenty cases of skeletal myxoid chondrosarcoma (SKMC). Ultrastructural examination (EMC = 8, SMC = 5) and molecular analysis (EMC = 12, SMC = 6) was available for a subset of these cases. The ultrastructural features of extraskeletal myxoid chondrosarcoma consisted of intracisternal microtubules (3/8 cases) and prominent mitochondria (4/8 cases). Skeletal myxoid chondrosarcoma exhibited no distinctive ultrastructural features. Molecular analysis demonstrated the presence of the EWS/CHN fusion gene transcript, the expression of the translocation t(9;22), in extraskeletal myxoid chondrosarcoma (7/12 cases) and the absence of this fusion gene transcript in skeletal myxoid chondrosarcoma (0/6). The differences between extraskeletal myxoid chondrosarcoma and skeletal myxoid chondrosarcoma were apparent in the ultrastructural and molecular analyses of these two myxoid sarcomas that have similar light microscopic features as well as immunohistochemical profiles and biologic behavior. | ||
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