Anterior Mediastinal Mass -- Is it Thymoma?

Electron Microscopy:
As seen in Figure 3, the majority of the cells were small, mature lymphocytes. Scattered among thse were a few poorly preserved cells with relatively large nuclei having markedly disaggregated heterochromatin and a tiny nucleolus. Little cytoplasm remained, but some cellular frgaments appeared to be joined by desmosomes. At higher magnification (Fig. 4), many tissue fragments were indeed joined by well-formed desmosomes, some in close proximity to each other.
Figure 3. A relatively large nucleus is surrounded by remnants of cell membrane and cytoplasmic contents (C). A few desmosomes appear to join small cytoplasmic fragments (arrows). Figure 4. Higher magnification verifies that numerous desmosomes (arrows) join tissue fragments and that some of the desmosmes are closely associated with each other.

Diagnosis & Discussion