Irving Dardick
Department of Laboratory Medicine and Pathobiology
University of Toronto, Toronto, Canada
History:
This 35-year-old man had chronic back pain for about two years.
In 1985, CT scan showed a destructive lesion of the first lumbar
vertebra; calcification was present (Fig. 1). He underwent an
enbloc resection with a bone graft at that time. Recurrent tumor
was resected in both 1988 and 1989, and he also developed metastasis
to his right ileum in 1989. This was biopsied. An additional local
recurrence was resected in 1991. Because of two courses of radiation
for the recurrences and metastasis, he eventually developed paresis
of his lower limbs. He died of his tumor in 1993.
Light microscopy:
This neoplasm had the cellular characteristics and osteoid formation
of a typical osteogenic sarcoma (Fig. 2 and 3).
|
|
| Figure 1. |
|
|
| Figure 2. Cellular sarcoma with some degree of anaplasia and production of pink-staining extracellular material representing osteoid. | Figure 3. Higher magnification detailing the cellular and nuclear anaplasia and the formation of osteoid. |
