August 30, 1997

Solitary Coin Lesion in the Lung

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Electron Microscopy

Fine Needle Aspiration Cytology

CT guided, fine needle aspiration cytology of the solitary lung tumor yielded straw colored fluid. The cytologic smears from the aspirate contained only alveolar macrophages. Portions of the aspirate that were sent for bacterial culture yielded no organisms.

Gross Morphology

The resected lung parenchyma contained a circumscribed gray tumor that was 5.0 cm in maximum dimension. The cut surface of the tumor was gray-white, spongy and multicystic.

Light Microscopy

The tumor was sharply demarcated from the adjacent, normal lung parenchyma. It consisted of multiple cystic lined by low cuboidal cells. These spaces were more uniform in size at the periphery of the lesion and more irregularly sized in the central portion of the lesion. The cystic spaces contained alveolar type macrophages.The low cuboidal cells that lined the cystic spaces did not exhibit either nuclear pleomorphism or mitotic activity.

Figure 1Figure 1. (Hematoxylin and Eosin Original Magnification 160X)
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Variably sized spaces are focally lined by low cuboidal cells. The septa contain spindle cells and amorphous material and cells are present in the cystic spaces.


Figure 2

Figure 2. (Hematoxylin and Eosin Original Magnification 400X)
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Low cuboidal cells are focally present on thin septa and alveolar macrophages are present in the cystic spaces.


September 1997 Case-of-the-Month

© 1997 Society for Ultrastructural Pathology
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