A Rare, Mixed Neuronal-glial Tumor of the Central Nervous System |
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Sections Clinical History Imaging Studies Light Microscopy Electron Microscopy Diagnosis Discussion Reader Feedback |
Light Microscopy |
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| The tumor consists of an admixture of neoplastic neurons within a fibrillary, glial background. | ||
 Figure 3. Magnify Image |
There is a focal, perivascular aggregate of inflammatory cells. | |
 Figure 4. Magnify Image |
Focal areas of sclerosis were also present. | |
  Figure 5a, 5b. Magnify Image |
The reticulin stain demonstrated condensation of reticulin fibres in the area of sclerosis. The remainder of the tumor had a rich array of reticulin fibres. | |
   Figures 6a, 6b, 6c Magnify Image |
Neoplastic neurons had prominent, eosinophilic cytoplasm and nuclei that contained a central inclusion type nucleolus. These neurons occurred singly as well as in groups. Rare, binucleate neurons were identified. | |
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Immunohistochemistry There was positive staining of the neurons for vasoactive (VIP) immunopeptide and vimentin. An occasional neuron exhibited weak staining for glial fibrillary acidic protein (GFAP). The neuropil showed no staining for GFAP and strong staining for vimentin. |
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| Electron Microscopy | ||
| November 1997 Case-of-the-Month | ||