• Clinical History
• Light Microscopy
• Electron Microscopy
• Diagnosis and Comment
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  
  

Electron Microscopy

Light Microscopy

Microscopic examination of the biopsy showed a moderately cellular fibrillar neoplasm with modest nuclear pleomorphism and an absence of mitotic figures. The atypical cells composing the mass contained abundant eosinophilic cytoplasm and eccentrically-placed nuclei (Figures 1,2). Neither vascular proliferation nor coagulative tumor necrosis were present. Immunohistochemical studies with antibodies to GFA protein showed strong immunoreactivity within the neoplastic cells (Figure 3). A diagnosis of anaplastic astrocytoma with gemistocytic features was made.

Fig 1. H & E stained section, x200.	Fig 2. H & E stained section, x400.